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Link de la búsquedaCardiovascular Mathematics / SpringerLink (Online service) ; Luca Formaggia ; Alfio Quarteroni ; Alessandro Veneziani (2009)
Título : Cardiovascular Mathematics : Modeling and simulation of the circulatory system Tipo de documento: documento electrónico Autores: SpringerLink (Online service) ; Luca Formaggia ; Alfio Quarteroni ; Alessandro Veneziani Editorial: Milano : Springer Milan Fecha de publicación: 2009 Colección: MS&A, ISSN 2037-5255 num. 1 Número de páginas: XIII, 522 p Il.: online resource ISBN/ISSN/DL: 978-88-470-1152-6 Idioma : Inglés (eng) Palabras clave: Mathematics Cardiology Partial differential equations Applied mathematics Engineering Mathematical models Biomathematics Applications of and Computational Biology Physiological, Cellular Medical Topics Modeling Industrial Differential Equations Clasificación: 51 Matemáticas Resumen: Cardiovascular diseases have a major impact in Western countries. Mathematical models and numerical simulations can help the understanding of physiological and pathological processes, complementing the information provided to medical doctors by medical imaging and other non-invasive means, and opening the possibility of a better diagnosis and more in-depth surgical planning.This book offers a mathematically sound and up-to-date foundation to the training of researchers, and serves as a useful reference for the development of mathematical models and numerical simulation codes. It is structured into different chapters, written by recognized experts in the field, and however it features a common thread, with consistency of notation and expressions and systematic cross-referencing. Many fundamental issues are faced, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls; the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and simulation techniques. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling how the cardiovascular system works Nota de contenido: Physiology and pathology of the cardiovascular system: A physical perspective -- Basic mathematical models and motivations -- The derivation of the equations for fluids and structure -- From image data to computational domains -- Geometry and flow -- Rheological models for blood -- Mathematical models of mass transfer in the vascular walls -- Analysis of coupled models for fluid-structure interaction of internal flows -- Algorithms for fluid-structure interaction problems -- Reduced models of the cardiovascular system -- Multiscale models of the vascular system -- Applications and test cases En línea: http://dx.doi.org/10.1007/978-88-470-1152-6 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34129 Cardiovascular Mathematics : Modeling and simulation of the circulatory system [documento electrónico] / SpringerLink (Online service) ; Luca Formaggia ; Alfio Quarteroni ; Alessandro Veneziani . - Milano : Springer Milan, 2009 . - XIII, 522 p : online resource. - (MS&A, ISSN 2037-5255; 1) .
ISBN : 978-88-470-1152-6
Idioma : Inglés (eng)
Palabras clave: Mathematics Cardiology Partial differential equations Applied mathematics Engineering Mathematical models Biomathematics Applications of and Computational Biology Physiological, Cellular Medical Topics Modeling Industrial Differential Equations Clasificación: 51 Matemáticas Resumen: Cardiovascular diseases have a major impact in Western countries. Mathematical models and numerical simulations can help the understanding of physiological and pathological processes, complementing the information provided to medical doctors by medical imaging and other non-invasive means, and opening the possibility of a better diagnosis and more in-depth surgical planning.This book offers a mathematically sound and up-to-date foundation to the training of researchers, and serves as a useful reference for the development of mathematical models and numerical simulation codes. It is structured into different chapters, written by recognized experts in the field, and however it features a common thread, with consistency of notation and expressions and systematic cross-referencing. Many fundamental issues are faced, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls; the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and simulation techniques. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling how the cardiovascular system works Nota de contenido: Physiology and pathology of the cardiovascular system: A physical perspective -- Basic mathematical models and motivations -- The derivation of the equations for fluids and structure -- From image data to computational domains -- Geometry and flow -- Rheological models for blood -- Mathematical models of mass transfer in the vascular walls -- Analysis of coupled models for fluid-structure interaction of internal flows -- Algorithms for fluid-structure interaction problems -- Reduced models of the cardiovascular system -- Multiscale models of the vascular system -- Applications and test cases En línea: http://dx.doi.org/10.1007/978-88-470-1152-6 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34129 Ejemplares
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Título : Computing the Electrical Activity in the Heart Tipo de documento: documento electrónico Autores: Joakim Sundnes ; SpringerLink (Online service) ; Glenn Terje Lines ; Xing Cai ; Bjørn Frederik Nielsen ; Kent-Andre Mardal ; Aslak Tveito Editorial: Berlin, Heidelberg : Springer Berlin Heidelberg Fecha de publicación: 2006 Colección: Monographs in Computational Science and Engineering, ISSN 1863-0111 num. 1 Número de páginas: XII, 318 p. 99 illus., 18 illus. in color Il.: online resource ISBN/ISSN/DL: 978-3-540-33437-8 Idioma : Inglés (eng) Palabras clave: Mathematics Cardiology Bioinformatics Computational biology Computer mathematics Mathematical models Biomathematics Applied Engineering Science and Appl.Mathematics/Computational Methods of Physiological, Cellular Medical Topics Modeling Industrial Appl. in Life Sciences Clasificación: 51 Matemáticas Resumen: This book describes mathematical models and numerical techniques for simulating the electrical activity in the heart. The book gives an introduction to the most important models of the field, followed by a detailed description of numerical techniques for the models. Particular focus is on efficient numerical methods for large scale simulations on both scalar and parallel computers. The results presented in the book will be of particular interest to researchers in bioengineering and computational biology, who face the challenge of solving these complex mathematical models efficiently. The book will also serve as a valuable introduction to a new and exciting field for computational scientists and applied mathematicians Nota de contenido: Physiological Background -- Mathematical Models -- Computational Models -- Solving Linear Systems -- Solving Systems of ODEs -- Large-Scale Electrocardiac Simulations -- Inverse Problems En línea: http://dx.doi.org/10.1007/3-540-33437-8 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34960 Computing the Electrical Activity in the Heart [documento electrónico] / Joakim Sundnes ; SpringerLink (Online service) ; Glenn Terje Lines ; Xing Cai ; Bjørn Frederik Nielsen ; Kent-Andre Mardal ; Aslak Tveito . - Berlin, Heidelberg : Springer Berlin Heidelberg, 2006 . - XII, 318 p. 99 illus., 18 illus. in color : online resource. - (Monographs in Computational Science and Engineering, ISSN 1863-0111; 1) .
ISBN : 978-3-540-33437-8
Idioma : Inglés (eng)
Palabras clave: Mathematics Cardiology Bioinformatics Computational biology Computer mathematics Mathematical models Biomathematics Applied Engineering Science and Appl.Mathematics/Computational Methods of Physiological, Cellular Medical Topics Modeling Industrial Appl. in Life Sciences Clasificación: 51 Matemáticas Resumen: This book describes mathematical models and numerical techniques for simulating the electrical activity in the heart. The book gives an introduction to the most important models of the field, followed by a detailed description of numerical techniques for the models. Particular focus is on efficient numerical methods for large scale simulations on both scalar and parallel computers. The results presented in the book will be of particular interest to researchers in bioengineering and computational biology, who face the challenge of solving these complex mathematical models efficiently. The book will also serve as a valuable introduction to a new and exciting field for computational scientists and applied mathematicians Nota de contenido: Physiological Background -- Mathematical Models -- Computational Models -- Solving Linear Systems -- Solving Systems of ODEs -- Large-Scale Electrocardiac Simulations -- Inverse Problems En línea: http://dx.doi.org/10.1007/3-540-33437-8 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34960 Ejemplares
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Título : Fluid-Structure Interaction : Modelling, Simulation, Optimisation Tipo de documento: documento electrónico Autores: SpringerLink (Online service) ; Hans-Joachim Bungartz ; Schäfer, Michael Editorial: Berlin, Heidelberg : Springer Berlin Heidelberg Fecha de publicación: 2006 Colección: Lecture Notes in Computational Science and Engineering, ISSN 1439-7358 num. 53 Número de páginas: VIII, 394 p. 251 illus Il.: online resource ISBN/ISSN/DL: 978-3-540-34596-1 Idioma : Inglés (eng) Palabras clave: Engineering Cardiology Computer mathematics Physics Applied Fluid mechanics Dynamics Computational Science and Theoretical, Mathematical Appl.Mathematics/Computational Methods of Clasificación: 51 Matemáticas Resumen: Fluid-structure interactions (FSI), that is interactions of some movable or deformable structure with an internal or surrounding fluid flow, are among the most important and, with respect to both modelling and computational issues, the most challenging multi-physics problems. The variety of FSI occurrences is abundant and ranges from tent-roofs to micropumps, from parachutes via airbags to blood flow in arteries. This volume of LNCSE contains a collection of papers presented at the International Workshop on FSI held in October 2005 in Hohenwart and organized by DFG's Research Unit 493 "FSI: Modelling, Simulation, and Optimization". The papers address partitioned and monolithic coupling approaches, methodical issues and applications, and discuss FSI from the mathematical, informatical, and engineering point of view Nota de contenido: Implicit Coupling of Partitioned Fluid-Structure Interaction Solvers using Reduced-Order Models -- oomph-lib – An Object-Oriented Multi-Physics Finite-Element Library -- Modeling of Fluid-Structure Interactions with the Space-Time Techniques -- Extending the Range and Applicability of the Loose Coupling Approach for FSI Simulations -- A New Fluid Structure Coupling Method for Airbag OOP -- Adaptive Finite Element Approximation of Fluid-Structure Interaction Based on an Eulerian Variational Formulation -- A Monolithic FEM/Multigrid Solver for an ALE Formulation of Fluid-Structure Interaction with Applications in Biomechanics -- An Implicit Partitioned Method for the Numerical Simulation of Fluid-Structure Interaction -- Large Deformation Fluid-Structure Interaction – Advances in ALE Methods and New Fixed Grid Approaches -- Fluid-Structure Interaction on Cartesian Grids: Flow Simulation and Coupling Environment -- Lattice-Boltzmann Method on Quadtree-Type Grids for Fluid-Structure Interaction -- Thin Solids for Fluid-Structure Interaction -- Algorithmic Treatment of Shells and Free Form-Membranes in FSI -- Experimental Study on a Fluid-Structure Interaction Reference Test Case -- Proposal for Numerical Benchmarking of Fluid-Structure Interaction between an Elastic Object and Laminar Incompressible Flow En línea: http://dx.doi.org/10.1007/3-540-34596-5 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34980 Fluid-Structure Interaction : Modelling, Simulation, Optimisation [documento electrónico] / SpringerLink (Online service) ; Hans-Joachim Bungartz ; Schäfer, Michael . - Berlin, Heidelberg : Springer Berlin Heidelberg, 2006 . - VIII, 394 p. 251 illus : online resource. - (Lecture Notes in Computational Science and Engineering, ISSN 1439-7358; 53) .
ISBN : 978-3-540-34596-1
Idioma : Inglés (eng)
Palabras clave: Engineering Cardiology Computer mathematics Physics Applied Fluid mechanics Dynamics Computational Science and Theoretical, Mathematical Appl.Mathematics/Computational Methods of Clasificación: 51 Matemáticas Resumen: Fluid-structure interactions (FSI), that is interactions of some movable or deformable structure with an internal or surrounding fluid flow, are among the most important and, with respect to both modelling and computational issues, the most challenging multi-physics problems. The variety of FSI occurrences is abundant and ranges from tent-roofs to micropumps, from parachutes via airbags to blood flow in arteries. This volume of LNCSE contains a collection of papers presented at the International Workshop on FSI held in October 2005 in Hohenwart and organized by DFG's Research Unit 493 "FSI: Modelling, Simulation, and Optimization". The papers address partitioned and monolithic coupling approaches, methodical issues and applications, and discuss FSI from the mathematical, informatical, and engineering point of view Nota de contenido: Implicit Coupling of Partitioned Fluid-Structure Interaction Solvers using Reduced-Order Models -- oomph-lib – An Object-Oriented Multi-Physics Finite-Element Library -- Modeling of Fluid-Structure Interactions with the Space-Time Techniques -- Extending the Range and Applicability of the Loose Coupling Approach for FSI Simulations -- A New Fluid Structure Coupling Method for Airbag OOP -- Adaptive Finite Element Approximation of Fluid-Structure Interaction Based on an Eulerian Variational Formulation -- A Monolithic FEM/Multigrid Solver for an ALE Formulation of Fluid-Structure Interaction with Applications in Biomechanics -- An Implicit Partitioned Method for the Numerical Simulation of Fluid-Structure Interaction -- Large Deformation Fluid-Structure Interaction – Advances in ALE Methods and New Fixed Grid Approaches -- Fluid-Structure Interaction on Cartesian Grids: Flow Simulation and Coupling Environment -- Lattice-Boltzmann Method on Quadtree-Type Grids for Fluid-Structure Interaction -- Thin Solids for Fluid-Structure Interaction -- Algorithmic Treatment of Shells and Free Form-Membranes in FSI -- Experimental Study on a Fluid-Structure Interaction Reference Test Case -- Proposal for Numerical Benchmarking of Fluid-Structure Interaction between an Elastic Object and Laminar Incompressible Flow En línea: http://dx.doi.org/10.1007/3-540-34596-5 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34980 Ejemplares
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Título : New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients Tipo de documento: documento electrónico Autores: SpringerLink (Online service) ; Niccolò Grieco ; Maurizio Marzegalli ; Anna Maria Paganoni Editorial: Milano : Springer Milan Fecha de publicación: 2013 Otro editor: Imprint: Springer Colección: Contributions to Statistics, ISSN 1431-1968 Número de páginas: VIII, 136 p Il.: online resource ISBN/ISSN/DL: 978-88-470-5379-3 Idioma : Inglés (eng) Palabras clave: Statistics Health administration Cardiology economics Medical for Life Sciences, Medicine, Sciences Economics Administration Clasificación: 51 Matemáticas Resumen: This book collects several contributions, written both by statisticians and medical doctors, which focus on the identification of new diagnostic, therapeutic and organizational strategies in order to improve the occurrence of clinical outcomes for Acute Coronary Syndromes (ACS) patients. The work is structured in two different parts: the first one is focused on cooperative project mainly on statistical analysis of large clinical and administrative databases; the second one faces the development of innovative diagnostic techniques, with specific reference to genetic and proteomic, and the evolution of new imaging techniques for the early identification of patients at major risk of thrombotic, arrhythmic complications and at risk of poor revascularization Nota de contenido: Part I Organizational Strategies in ACS -- Gender Differences in Hospitalization for Acute Myocardial Infarction in Lombardy During the Years 2000-2010 -- Heart Diseases Registries Based on Healthcare Databases -- Designing and Mining a Multicenter Observational Clinical Registry Concerning Patients with Acute Coronary Syndromes -- Statistical Methods to Study the Representativeness of STEMI Archive -- Using Text Mining to Validate Diagnoses of Acute Myocardial Infarction -- Part II New Diagnostic and Therapeutic Strategies in ACS -- PREDESTINATION – Primary Ventricular Fibrillation and Sudden Death During a First Myocardial Infarction: Genetic Basis -- micro RNAs and Tissue Response to Acute Ischemia -- The Role of Cardiac Magnetic Resonance in Selecting Patients with Left Ventricular Dysfunction Undergoing Surgical Ventricular Reconstruction -- Chronic Kidney Disease in Acute Myocardial Infarction: Clinical Relevance and Novel Potential Fields of Investigation En línea: http://dx.doi.org/10.1007/978-88-470-5379-3 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=32638 New Diagnostic, Therapeutic and Organizational Strategies for Acute Coronary Syndromes Patients [documento electrónico] / SpringerLink (Online service) ; Niccolò Grieco ; Maurizio Marzegalli ; Anna Maria Paganoni . - Milano : Springer Milan : Imprint: Springer, 2013 . - VIII, 136 p : online resource. - (Contributions to Statistics, ISSN 1431-1968) .
ISBN : 978-88-470-5379-3
Idioma : Inglés (eng)
Palabras clave: Statistics Health administration Cardiology economics Medical for Life Sciences, Medicine, Sciences Economics Administration Clasificación: 51 Matemáticas Resumen: This book collects several contributions, written both by statisticians and medical doctors, which focus on the identification of new diagnostic, therapeutic and organizational strategies in order to improve the occurrence of clinical outcomes for Acute Coronary Syndromes (ACS) patients. The work is structured in two different parts: the first one is focused on cooperative project mainly on statistical analysis of large clinical and administrative databases; the second one faces the development of innovative diagnostic techniques, with specific reference to genetic and proteomic, and the evolution of new imaging techniques for the early identification of patients at major risk of thrombotic, arrhythmic complications and at risk of poor revascularization Nota de contenido: Part I Organizational Strategies in ACS -- Gender Differences in Hospitalization for Acute Myocardial Infarction in Lombardy During the Years 2000-2010 -- Heart Diseases Registries Based on Healthcare Databases -- Designing and Mining a Multicenter Observational Clinical Registry Concerning Patients with Acute Coronary Syndromes -- Statistical Methods to Study the Representativeness of STEMI Archive -- Using Text Mining to Validate Diagnoses of Acute Myocardial Infarction -- Part II New Diagnostic and Therapeutic Strategies in ACS -- PREDESTINATION – Primary Ventricular Fibrillation and Sudden Death During a First Myocardial Infarction: Genetic Basis -- micro RNAs and Tissue Response to Acute Ischemia -- The Role of Cardiac Magnetic Resonance in Selecting Patients with Left Ventricular Dysfunction Undergoing Surgical Ventricular Reconstruction -- Chronic Kidney Disease in Acute Myocardial Infarction: Clinical Relevance and Novel Potential Fields of Investigation En línea: http://dx.doi.org/10.1007/978-88-470-5379-3 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=32638 Ejemplares
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Título : Problems of High Altitude Medicine and Biology Tipo de documento: documento electrónico Autores: SpringerLink (Online service) ; Almaz Aldashev ; Robert Naeije Editorial: Dordrecht : Springer Netherlands Fecha de publicación: 2007 Número de páginas: VIII, 306 p Il.: online resource ISBN/ISSN/DL: 978-1-4020-6300-8 Idioma : Inglés (eng) Palabras clave: Mathematics Cardiology Respiratory organs Diseases Sports medicine Biomathematics Physiological, Cellular and Medical Topics Medicine Pneumology/Respiratory System Clasificación: 51 Matemáticas Resumen: The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20] Nota de contenido: Introduction: 45 Years Of Mountain Medicine -- High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases -- The Cellular Effects Of Hypoxia In The Pulmonary Circulation -- Angiogenesis And Chronic Hypoxic Pulmonary Hypertension -- Tetrahydrobiopterin And Pulmonary Hypertension -- Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53 -- Pulmonary Adaptation To High Altitude In Wild Mammals -- The Lung At High Altitude: Between Physiology And Pathology -- Sildenafil And Hypoxic Pulmonary Hypertension -- The Role Of Antioxidants In Modulation Of Acclimatization Processes -- Gene Polymorphisms And High Altitude Pulmonary Hypertension -- Genetic Factors In The Acute Response To Hypoxia In Animals Models -- Who Gets High Altitude Pulmonary Edema And Why? -- Effects Of Inhaled Nitric Oxide And Oxygen In High Altitude Pulmonary Edema -- Altered Autoregulation Of Cerebral Blood Flow In Hypoxia: Relevance To The Pathophysiology Of Acute Mountain Sickness -- Cardiac Limitation To Exercise Capacity At High Altitudes -- Pediatric High Altitude Heart Disease: A Hypoxic Pulmonary Hypertension Syndrome -- Clinical And Functional Features Of Chronic Obstructive Pulmonary Disease In The Highlanders Of Kyrgzstan -- Monitoring The Morphological And Functional Parameters Of Platelets In Patients With Thrombocytopenic Purpura During High Mountain Treatment -- Role Of Exogenous Hypoxia In Treatment Of Chronic Glomerulonephritis -- Atherogenesis Of Brain Vessels In Conditions Of Hypoxia In Kyrgyz Highlanders -- Particularities Of Neuropsychotropic Effects Of Mexidol In Various Altitude Conditions -- Influence Of High-Altitude Hypoxia On Adaptive And Non-Adaptive Structural Changes In The Vessels Of The Pulmonary Circulation -- Acute Oxygen Sensing Mechanisms En línea: http://dx.doi.org/10.1007/978-1-4020-6300-8 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34582 Problems of High Altitude Medicine and Biology [documento electrónico] / SpringerLink (Online service) ; Almaz Aldashev ; Robert Naeije . - Dordrecht : Springer Netherlands, 2007 . - VIII, 306 p : online resource.
ISBN : 978-1-4020-6300-8
Idioma : Inglés (eng)
Palabras clave: Mathematics Cardiology Respiratory organs Diseases Sports medicine Biomathematics Physiological, Cellular and Medical Topics Medicine Pneumology/Respiratory System Clasificación: 51 Matemáticas Resumen: The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20] Nota de contenido: Introduction: 45 Years Of Mountain Medicine -- High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases -- The Cellular Effects Of Hypoxia In The Pulmonary Circulation -- Angiogenesis And Chronic Hypoxic Pulmonary Hypertension -- Tetrahydrobiopterin And Pulmonary Hypertension -- Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53 -- Pulmonary Adaptation To High Altitude In Wild Mammals -- The Lung At High Altitude: Between Physiology And Pathology -- Sildenafil And Hypoxic Pulmonary Hypertension -- The Role Of Antioxidants In Modulation Of Acclimatization Processes -- Gene Polymorphisms And High Altitude Pulmonary Hypertension -- Genetic Factors In The Acute Response To Hypoxia In Animals Models -- Who Gets High Altitude Pulmonary Edema And Why? -- Effects Of Inhaled Nitric Oxide And Oxygen In High Altitude Pulmonary Edema -- Altered Autoregulation Of Cerebral Blood Flow In Hypoxia: Relevance To The Pathophysiology Of Acute Mountain Sickness -- Cardiac Limitation To Exercise Capacity At High Altitudes -- Pediatric High Altitude Heart Disease: A Hypoxic Pulmonary Hypertension Syndrome -- Clinical And Functional Features Of Chronic Obstructive Pulmonary Disease In The Highlanders Of Kyrgzstan -- Monitoring The Morphological And Functional Parameters Of Platelets In Patients With Thrombocytopenic Purpura During High Mountain Treatment -- Role Of Exogenous Hypoxia In Treatment Of Chronic Glomerulonephritis -- Atherogenesis Of Brain Vessels In Conditions Of Hypoxia In Kyrgyz Highlanders -- Particularities Of Neuropsychotropic Effects Of Mexidol In Various Altitude Conditions -- Influence Of High-Altitude Hypoxia On Adaptive And Non-Adaptive Structural Changes In The Vessels Of The Pulmonary Circulation -- Acute Oxygen Sensing Mechanisms En línea: http://dx.doi.org/10.1007/978-1-4020-6300-8 Link: https://biblioteca.cunef.edu/gestion/catalogo/index.php?lvl=notice_display&id=34582 Ejemplares
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